PAN Pesticides Database - Chemicals

Warfarin - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information

Note: See Working with the Information on this Page section below for important notes about this data.

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Identifying information, including synonyms, ID numbers, use type, chemical classification, a link to a list of all products containing this chemical and a list of the top crops this pesticide is used on in California.
Signs and symptoms of poisoning, first aid, and links to treatment information for this chemical.
Link to information on toxicity to humans, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity.
Links to world-wide registration status as well as regulatory information for the U.S. and California.
Water quality standards and physical properties affecting water contamination potential.
Toxicity to aquatic organisms.
List of chemicals in the same family, including breakdown products, salts, esters, isomers, and other derivatives.
 

Chemical Identification and Use for Warfarin

Basic Identification Information About This Chemical
Chemical Name: Warfarin
CAS Number: 81-81-2
U.S. EPA PC Code: 086002
CA DPR Chem Code: 621
Molecular Weight: 308.33
Molecular Structure:
Use Type: Drug , Rodenticide
Chem Class: Coumarin
View Related Chemicals
 
Additional Resources About This Chemical Class and Use Type
Historical Use of this Chemical
Top five crops and sites for this pesticide in California
Structural Pest Control   Right of Way   Landscape   Lemons   Dates  
View All Crops and Sites
 
Other Names for this Chemical
About Chemical Synonyms
(US EPA PC Code ) , 086002 (US EPA PC Code Text ) , 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)- , 3-(1-Phenyl-2-acetylethyl)-4-hydroxycoumarin , 3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin , 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one , 621 (CA DPR Chem Code) ) , 81-81-2 (CAS number) , 81812 , 81812 (CAS number without hyphens) , Coumafene (France) , Coumafene (France) , Coumarin, 3-(.alpha.-acetonylbenzyl)-4-hydroxy- , Cumafeno , Cumafeno , Dethmor ( Warfarin product, cnx 7/87 ) , Dethmor ( Warfarin product, cnx 7/87 ) , ENT-17033 , Warfarin , WARFARIN (CA DPR Chem Code Text ) , WARFARIN (PRESENT IN FREE FORM OR AS SODIUM SALT) , Warfarina , Zoocoumarin (Netherlands and USSR) , Zoocoumarin (Netherlands and USSR)
 
Products Containing This Chemical
Current and historic U.S. registered products
View U.S. Products All Products Currently Registered Products
 

Signs and Symptoms of Warfarin Poisoning

NOTE! There may be other diseases and chemicals that have similar symptoms.

If you have a poisoning emergency in the United States call 1-800-222-1222.
If the victim has collapsed or is unconscious, call 911.

Warfarin is a Coumarin or Indandione compound.

Report a Poisoning

Symptoms of Poisoning with Coumarin or Indandione Compounds
Find Products Containing this Chemical

- Nosebleeds, bleeding gums, bloody urine, extensive bruising in the absence of injury (ecchymoses).
- Fatigue, shortness of breath (dyspnea) on exertion.
- May cause fluid in lungs (pulmonary edema).

Source for Group Symptoms: Recognition and Management of Pesticide Poisoning, 5th edition, U.S. EPA, Chapter 17.

Treatment for Coumarin or Indandione Poisoning

See: Recognition and Management of Pesticide Poisoning, 5th edition, U.S. EPA, Chapter 17, page 170.

 
Symptoms of Warfarin Exposure from the International Chemical Safety Cards (ICSC)

Report a Poisoning

View full ICSC Cards: English   Español   Française   Chinese   Dutch   Finnish   German   Hungarian   Japanese   Swahili   Thai   Urdu  
NOTE! PREVENT DISPERSION OF DUST! AVOID EXPOSURE OF (PREGNANT) WOMEN!
General First Aid: IN ALL CASES CONSULT A DOCTOR!

Route of Exposure

Symptoms

First Aid

Inhalation (See Ingestion). Fresh air rest. Refer for medical attention.
Skin MAY BE ABSORBED! Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes First rinse with plenty of water for several minutes (remove contact lenses if easily possible) then take to a doctor.
Ingestion Bleeding pinpoint purplish-red spots (see Notes). Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give plenty of water to drink. Refer for medical attention.
Notes for ICSC Information
Warfarin is usually available commercially as the water soluble sodium salt. The physical properties above refer to the parent substance. The substance is combustible but no flash point is available in literature. The symptoms of bleeding do not become manifest until several days later. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Do NOT take working clothes home. Athrombine-K Brumolin Compound 42 Coumadin d-CON Kumadu Mar-frin Maveran Ratoxin Temus W Warf Compound 42 and Warficide are trade names.
 

Toxicity Information for Warfarin

  Note: Information for many chemicals is incomplete and may not be fully representative of effects on humans. Why?

Summary Toxicity Information

PAN Bad Actor
Chemical
1
Acute
Toxicity
2
Carcinogen Cholinesterase
Inhibitor
Ground
Water Contaminant
Developmental or
Reproductive Toxin
Endocrine
Disruptor
No
 
Indicates high toxicity in the given toxicological category. Indicates no available weight-of-the-evidence summary assessment. For additional information on toxicity from scientific journals or registration documents, see the "Additional Resources for Toxicity " section of the chemical detail page.
1. PAN Bad Actors are chemicals that are one or more of the following: highly acutely toxic, cholinesterase inhibitor, known/probable carcinogen, known groundwater pollutant or known reproductive or developmental toxicant. NOTE! Because there are no authoritative lists of Endocrine Disrupting (ED) chemicals, EDs are not yet considered PAN Bad Actor chemicals.
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.

Detailed Toxicity Information

Acute Toxicity 2
Warfarin
WHO Acute Hazard
TRI Acute Hazard
Material Safety Data Sheets
Acute rating from U.S. EPA product label
U.S. NTP Acute Toxicity Studies
      View Studies
Cholinesterase Inhibitor
Ib, Highly Hazardous
Not Listed
Not Available
Highly Toxic
Slightly to Moderately Toxic

No
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.
 
Cancer Information
Warfarin
IARC Carcinogens
U.S. NTP Carcinogens
California Prop 65 Known Carcinogens
U.S. EPA Carcinogens
TRI Carcinogen
Not Listed
Not Listed
Not Listed
No data available
Not Listed
 
Endocrine Disruption
Warfarin
Illinois EPA list
Keith list
Colborn list
Benbrook list
Danish Inert list
EU list
Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
 
Reproductive and Developmental Toxicity
Warfarin
CA Prop 65 Developmental Toxin
U.S. TRI Developmental Toxin
CA Prop 65 Female Reproductive Toxin
CA Prop 65 Male Reproductive Toxin
U.S. TRI Reproductive Toxin
Yes
Yes
Not Listed
Not Listed
Not Listed
 
Chemicals of Special Concern
Warfarin
PAN Bad Actors
PAN Dirty Dozen list
Yes
Not Listed
 

Water Pollution Potential and Criteria for Warfarin

Water Pollution Potential

PAN Ground Water Contaminant Rating Insufficient Data
 
Physical Property Data Related to Water Contamination Potential
Water Solubility (Avg, mg/L)
Adsorption Coefficient (Koc)
Hydrolysis Half-life (Avg, Days)
Aerobic Soil Half-life (Avg, Days)
Anaerobic Soil Half-life (Avg, Days)
267.0
174.0
-
5.00
-
 
 

Sorry, no water quality standards or criteria have been established for this chemical by the U.S. or Canadian governments; however, there may be criteria established for related chemicals.

 

Regulatory Information for Warfarin

International Regulatory Status

 
UNEP Persistent Organic Pollutant (POP)
UNEP Prior Informed Consent Chemical (PIC)
WHO Obsolete Pesticide
Not Listed
Not Listed
Not Listed
 

U.S. and California Regulatory Status

U.S. EPA Registered
U.S. EPA Hazardous Air Pollutant
U.S. EPA Minimum Risk Pesticide (25b list)

CA Registered
CA Groundwater Contaminant
CA Toxic Air Contaminant
Yes
Not Listed
No

Yes
Not Listed
Not Listed
 

Maximum Tolerance and Residue Levels

Codex Alimentarius
   (UN FAO Maximum Residue Limits)
U.S. Maximum Tolerance Levels
European Union Maximum Residue Levels
Go to web site

Go to web site

Go to web site
 

Ecotoxicity for Warfarin

Note! Information for many chemicals is incomplete and may not be fully representative of effects on the environment. Why? Click on underlined terms for definitions and additional information.

Aquatic Ecotoxicity

All Toxic Effects for Organism Group
Organism Group Effects Noted
Crustaceans Mortality
Fish Mortality
Zooplankton Intoxication, Mortality
View All Aquatic Ecotoxicity Studies and References
 
Summary of Acute Toxicity for Organism Group
Organism Group Average Acute Toxicity Acute Toxicity Range
Crustaceans Not Acutely Toxic Not Acutely Toxic
Fish Not Acutely Toxic Not Acutely Toxic to Very High Toxicity
Zooplankton Not Acutely Toxic Not Acutely Toxic
View All Acute Summaries
 

Terrestrial Ecotoxicity

Summary of Acute Toxicity for Organism Group

Sorry, no honeybee acute toxicity data available for this chemical. Try related chemicals.

Note: Population-level effects on honeybees may occur even if a pesticide has low acute toxicity. For example, certain pesticides interfere with honeybee reproduction, ability to navigate, or temperature regulation, any of which can have an effect on long-term survival of honeybee colonies. The neonicotinoids, pyrethroids and keto-enol pesticides are some types of pesticides causing one or more of these effects.
Honeybee Chronic Toxicity

Sorry, no honeybee chronic toxicity data available for this chemical. Try related chemicals.

Related Chemicals for Warfarin

CAS Number Relation Reason Chemical Name Chem Detail Symptoms California Use Chem Use Type U.S. EPA Reg PAN Bad Actor
81-81-2 Parent P Warfarin View View View Rodenticide Yes Yes
90035-08-8 Related 13 Flocoumafen View View View Rodenticide No Yes
2610-86-8 Related 1 Potassium warfarin View View View Rodenticide No Yes
129-06-6 Related 1 Warfarin, sodium salt View View View Rodenticide No Yes
 
Working with the Information on this Page

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* Data marked with an asterisk indicates that this chemical is not explicitly listed on the corresponding list. Instead, it belongs to a group of chemicals that IS designated on the list. For example, if an agency assigns a classification of reproductive toxicant to "mercury compounds", that classification is applied to all mercury compounds in the PAN Pesticide database, which are then marked with an asterisk.

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