PAN Pesticides Database - Chemicals

Arsenic trioxide - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information

Note: See Working with the Information on this Page section below for important notes about this data.

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Identifying information, including synonyms, ID numbers, use type, chemical classification, a link to a list of all products containing this chemical and a list of the top crops this pesticide is used on in California.
Signs and symptoms of poisoning, first aid, and links to treatment information for this chemical.
Link to information on toxicity to humans, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity.
Links to world-wide registration status as well as regulatory information for the U.S. and California.
Water quality standards and physical properties affecting water contamination potential.
Toxicity to aquatic organisms.
List of chemicals in the same family, including breakdown products, salts, esters, isomers, and other derivatives.
 

Chemical Identification and Use for Arsenic trioxide

Basic Identification Information About This Chemical
Chemical Name: Arsenic trioxide
CAS Number: 1327-53-3
U.S. EPA PC Code: 007001
CA DPR Chem Code: 42
Molecular Weight: 197.84
Use Type: Herbicide , Insecticide , Rodenticide
Chem Class: Heavy metal , Inorganic-arsenic
View Related Chemicals
 
Additional Resources About This Chemical Class and Use Type
Historical Use of this Chemical
Top five crops and sites for this pesticide in California
Landscape  
View All Crops and Sites
 
Other Names for this Chemical
About Chemical Synonyms
(US EPA PC Code ) , 007001 (US EPA PC Code Text ) , 1327-53-3 (CAS number) , 1327533 , 1327533 (CAS number without hyphens) , 42 (CA DPR Chem Code) ) , Arsenic (III) oxide , Arsenic oxide (As2O3) , Arsenic oxide (As2O3) , Arsenic sesquioxide (As2O3) , Arsenic trioxide , ARSENIC TRIOXIDE (CA DPR Chem Code Text ) , Arsenic trioxide, solid , Arsenictrioxide , Arsenicum Album , Arsenous acid anhydride , Arsenous anhydride , Arsenous oxide , Diarsonic trioxide , White arsenic
 
Products Containing This Chemical
Current and historic U.S. registered products
View U.S. Products All Products Currently Registered Products
 

Signs and Symptoms of Arsenic trioxide Poisoning

NOTE! There may be other diseases and chemicals that have similar symptoms.

If you have a poisoning emergency in the United States call 1-800-222-1222.
If the victim has collapsed or is unconscious, call 911.

Arsenic trioxide is a Arsenical compound.

Report a Poisoning

Symptoms of Poisoning with Arsenical Compounds
Find Products Containing this Chemical

- Garlic odor of breath and feces, metallic taste in mouth.
- Adverse GI effects predominate with vomiting, abdominal pain and rice-water or bloody diarrhea. GI effects may also include inflammation, vesicle formation and eventual sloughing of the mucosa in the mouth, pharynx and esophagus.
- Central nervous system effects are common: headache, dizziness, drowsiness and confusion.
- Symptoms may progress to include muscle weakness and spasms, hypothermia, lethargy, delirium, coma and convulsions.
- Renal injury is manifest as proteinuria, hematuria, glycosuria, oliguria, casts in the urine and in severe poisoning cases, acute tubular necrosis.
- Cardiovascular effects include shock, cyanosis and cardiac arrhythmia.
- Liver damage may be manifested by elevated liver enzymes and jaundice.
- Injury to blood-forming tissues may cause anemia, leucopenia and thrombocytopenia.
Chronic exposure may lead to:
- Muscle weakness, fatigue, anorexia, weight loss.
- Hyperpigmentation, hyperkeratosis.
- Peripheral neuropathy, paresthesia, paresis and ataxia.
- Inability to coordinate voluntary muscular movements.
- Subcutaneous edema in face, eyelids, and ankles.
- Stomatitis, white striations across the nails (Mees lines) and sometimes loss of nails or hair.
- Liver toxicity as indicated by hepatomegaly, jaundice, cirrhosis.
- Renal toxicity leading to oliguria, proteinuria, and hematuria.
- EKG abnormalities and peripheral vascular disease.
- Hematologic abnormalities.
- Cancer.

Source for Group Symptoms: Recognition and Management of Pesticide Poisoning, 5th edition, U.S. EPA, Chapter 14.

Treatment for Arsenical Poisoning

See: Recognition and Management of Pesticide Poisoning, 5th edition, U.S. EPA, Chapter 14, page 129.

 
Symptoms of Arsenic trioxide Exposure from the International Chemical Safety Cards (ICSC)

Report a Poisoning

View full ICSC Cards: English   Español   Française   Chinese   Dutch   Finnish   German   Hungarian   Japanese   Swahili   Thai   Urdu  
NOTE! PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! AVOID EXPOSURE OF (PREGNANT) WOMEN!
General First Aid: IN ALL CASES CONSULT A DOCTOR!

Route of Exposure

Symptoms

First Aid

Inhalation Burning sensation. Cough. Dizziness. Headache. Shortness of breath. Sore throat. Weakness. Chest pain. Symptoms may be delayed (see Notes). (See Ingestion). Fresh air rest. Refer for medical attention.
Skin Dry skin. Redness. Skin burns. Pain. Blisters. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes Redness. Pain. Severe deep burns. Conjunctivitis. First rinse with plenty of water for several minutes (remove contact lenses if easily possible) then take to a doctor.
Ingestion Abdominal cramps. Abdominal pain. Burning sensation. Diarrhoea. Nausea. Vomiting. Muscular cramps. Shock. Death. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention.
Notes for ICSC Information
Physical properties depend on crystalline form of the substance. Depending on the degree of exposure periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. The symptoms of acute poisoning appear to 1 hour after the exposure but may be delayed many hours. No odour warning if toxic concentrations are present. Do NOT take working clothes home. The recommendations on this Card also apply to inorganic trivalent arsenic compounds (arsenites).
 

Toxicity Information for Arsenic trioxide

  Note: Information for many chemicals is incomplete and may not be fully representative of effects on humans. Why?

Summary Toxicity Information

PAN Bad Actor
Chemical
1
Acute
Toxicity
2
Carcinogen Cholinesterase
Inhibitor
Ground
Water Contaminant
Developmental or
Reproductive Toxin
Endocrine
Disruptor
No
Suspected
 
Indicates high toxicity in the given toxicological category. Indicates no available weight-of-the-evidence summary assessment. For additional information on toxicity from scientific journals or registration documents, see the "Additional Resources for Toxicity " section of the chemical detail page.
1. PAN Bad Actors are chemicals that are one or more of the following: highly acutely toxic, cholinesterase inhibitor, known/probable carcinogen, known groundwater pollutant or known reproductive or developmental toxicant. NOTE! Because there are no authoritative lists of Endocrine Disrupting (ED) chemicals, EDs are not yet considered PAN Bad Actor chemicals.
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.

Detailed Toxicity Information

This Chemical
Parent Chemical 
Acute Toxicity 2
Arsenic trioxide Arsenic
WHO Acute Hazard
TRI Acute Hazard
Material Safety Data Sheets
Acute rating from U.S. EPA product label
U.S. NTP Acute Toxicity Studies
      View Studies
Cholinesterase Inhibitor
Not Listed
Not Listed
Not Available
Highly Toxic
Highly Toxic

No
Not Listed
Not Listed
Not Available
No Consensus Value
No NTP Studies

No
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.
 
Cancer Information
Arsenic trioxide Arsenic
IARC Carcinogens
U.S. NTP Carcinogens
California Prop 65 Known Carcinogens
U.S. EPA Carcinogens
TRI Carcinogen
1, Known
Known
Yes
Not Listed
Not Listed
Not Listed
Known
Yes
Not Listed
Not Listed
 
Endocrine Disruption
Arsenic trioxide Arsenic
Illinois EPA list
Keith list
Colborn list
Benbrook list
Danish Inert list
EU list
Not Listed
Yes
Yes
Not Listed
Not listed
Not listed
Not Listed
Yes
Yes
Not Listed
Not listed
Not listed
 
Reproductive and Developmental Toxicity
Arsenic trioxide Arsenic
CA Prop 65 Developmental Toxin
U.S. TRI Developmental Toxin
CA Prop 65 Female Reproductive Toxin
CA Prop 65 Male Reproductive Toxin
U.S. TRI Reproductive Toxin
Yes
Not Listed
Not Listed
Not Listed
Not Listed
Yes
Not Listed
Not Listed
Not Listed
Not Listed
 
Chemicals of Special Concern
Arsenic trioxide Arsenic
PAN Bad Actors
PAN Dirty Dozen list
Yes
Not Listed
Yes
Not Listed
 

Water Pollution Potential and Criteria for Arsenic trioxide

Water Pollution Potential

This Chemical
Parent Chemical
  Arsenic trioxide Arsenic
PAN Ground Water Contaminant Rating Insufficient Data Insufficient Data
 

Sorry, no water quality standards or criteria have been established for this chemical by the U.S. or Canadian governments; however, there may be criteria established for related chemicals.

 

Regulatory Information for Arsenic trioxide

International Regulatory Status

This Chemical
Parent Chemical 
 
UNEP Persistent Organic Pollutant (POP)
UNEP Prior Informed Consent Chemical (PIC)
WHO Obsolete Pesticide
Not Listed
Not Listed
Yes
Not Listed
Not Listed
Not Listed
 

U.S. and California Regulatory Status

U.S. EPA Registered
U.S. EPA Hazardous Air Pollutant
U.S. EPA Minimum Risk Pesticide (25b list)

CA Registered
CA Groundwater Contaminant
CA Toxic Air Contaminant
No
Yes
No

No
Not Listed
HAPTAC, Pesti
No
Yes
No

No
Not Listed
HAPTAC, Indus
 

Maximum Tolerance and Residue Levels

Codex Alimentarius
   (UN FAO Maximum Residue Limits)
U.S. Maximum Tolerance Levels
European Union Maximum Residue Levels
Go to web site

Go to web site

Go to web site
 

Ecotoxicity for Arsenic trioxide

Note! Information for many chemicals is incomplete and may not be fully representative of effects on the environment. Why? Click on underlined terms for definitions and additional information.

Aquatic Ecotoxicity

All Toxic Effects for Organism Group
Organism Group Effects Noted
Amphibians Mortality
Annelida Accumulation, Mortality
AquaticPlants Mortality, Population
Crustaceans Mortality
Fish Accumulation, Behavior, Biochemistry, Enzyme(s), Feeding Behavior, Growth, Histology, Morphology, Mortality, No Effect Coded, Physiology, Population
Fungi Physiology
Insects Accumulation, Mortality
Molluscs Accumulation, Avoidance, Biochemistry, Growth, Intoxication, Mortality
NematodesandFlatworms Mortality
Phytoplankton Physiology
Zooplankton Accumulation, Growth, Intoxication, Mortality, No Effect Coded, Physiology, Population, Reproduction
~ Un-Assigned Accumulation, Mortality
View All Aquatic Ecotoxicity Studies and References
 
Summary of Acute Toxicity for Organism Group
Organism Group Average Acute Toxicity Acute Toxicity Range
Amphibians Highly Toxic Highly Toxic
Annelida Moderately Toxic Moderate Toxicity
Crustaceans Moderately Toxic Slight to Very High Toxicity
Fish Slightly Toxic Slight to Moderate Toxicity
Insects Slightly Toxic Slight Toxicity
Molluscs Moderately Toxic Moderate Toxicity
Zooplankton Moderately Toxic Slight to High Toxicity
View All Acute Summaries
 

Terrestrial Ecotoxicity

Summary of Acute Toxicity for Organism Group

Sorry, no honeybee acute toxicity data available for this chemical. Try related chemicals.

Note: Population-level effects on honeybees may occur even if a pesticide has low acute toxicity. For example, certain pesticides interfere with honeybee reproduction, ability to navigate, or temperature regulation, any of which can have an effect on long-term survival of honeybee colonies. The neonicotinoids, pyrethroids and keto-enol pesticides are some types of pesticides causing one or more of these effects.
Honeybee Chronic Toxicity

Sorry, no honeybee chronic toxicity data available for this chemical. Try related chemicals.

Related Chemicals for Arsenic trioxide

CAS Number Relation Reason Chemical Name Chem Detail Symptoms California Use Chem Use Type U.S. EPA Reg PAN Bad Actor
7440-38-2 Parent P Arsenic View View View Herbicide, Insecticide, Rodenticide No Yes
7784-44-3, 13462-93-6 Related 3 Ammonium arsenate View View View Herbicide, Insecticide, Rodenticide No Yes
Related 1 Ammonium iron methyl arsonate View View View No Not Listed
Related Arsenic (inorganic oxides) View View View Industrial chemical No Yes
7778-39-4 Related 3 Arsenic acid View View View Herbicide, Insecticide, Rodenticide Yes Yes
xx7440-38-2 Related 3 Arsenic and arsenic compounds View View View Herbicide, Rodenticide No Yes
x7440-38-2 Related 3 Arsenic compounds, inorganic View View View Herbicide, Rodenticide, Electronics production, Battery component, Building mate No Yes
56320-22-0 Related 3 Arsenic disulfide View View View Herbicide, Insecticide, Rodenticide No Yes
Related P Arsenic in drinking-water View View View No Yes
1303-28-2 Related 3 Arsenic pentoxide View View View Fungicide, Insecticide, Rodenticide, Herbicide Yes Yes
12612-21-4, 12344-68-2 Related 3 Arsenic sulfide View View View Herbicide, Insecticide, Rodenticide No Yes
1327-53-3 Related 3 Arsenic trioxide View View View Herbicide, Insecticide, Rodenticide No Yes
1303-33-9, 1303-34-0, 12044-79-0 Related 3 Arsenic trisulfide View View View Herbicide, Insecticide, Rodenticide No Yes
98-50-0 Related 3 Arsonic acid, (4-aminophenyl)- View View View No Yes
58829-95-1, 13462-94-7, 53404-17-4 Related 3 Arsonic acid, ammonium salt View View View Herbicide, Insecticide, Wood Preservative No Yes
16102-92-4 Related 3 Basic copper arsenate View View View Herbicide, Insecticide, Rodenticide No Yes
7778-44-1 Related 3 Calcium arsenate View View View Herbicide, Insecticide, Rodenticide, Molluscicide No Yes
53404-59-4 Related 3 Calcium arsenite View View View Herbicide, Insecticide, Rodenticide No Yes
10290-12-7 Related 3 Copper arsenite View View View Herbicide, Insecticide, Rodenticide No Yes
12002-03-8 Related 3 Cupric acetoarsenite View View View Wood Preservative No Yes
10103-50-1 Related 3 Magnesium arsenate View View View Herbicide, Insecticide, Rodenticide No Yes
7784-38-5 Related 3 Manganese arsenate View View View Herbicide, Insecticide, Rodenticide No Yes
10124-50-2, 13464-35-2 Related 3 Potassium arsenite View View View Herbicide, Insecticide, Rodenticide No Yes
17029-22-0 Related 3 Potassium hexafluoroarsenate View View View No Yes
13464-38-5 Related 3 Sodium arsenate View View View Herbicide, Insecticide, Rodenticide No Yes
7784-46-5 Related 3 Sodium arsenite View View View Herbicide, Insecticide, Rodenticide, Fungicide No Yes
13464-42-1 Related 3 Sodium pyroarsenate View View View Wood Preservative, Fungicide No Yes
17367-56-5, 16486-45-6, 26273-99-4 Related 3 Sodium thioarsenate View View View No Yes
 
Working with the Information on this Page

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